This trial demonstrates the multi-capabilities of BPC157 to repair and protect numerous organs in our body.
Inflammo Pharmacology Journal
March 1999, Volume 7, Issue 1, pp 1-14
The reported beneficial effects of the gastric mucosal derived pentadecapeptide BPC 157 (Gly Glu Pro Pro Pro Gly Lys Pro Ala Asp Asp Ala Gly Leu Val, M.W. 1419) on different organ lesions are reviewed.
Apart from the effects on various gastrointestinal lesions, the potentially beneficial effect on pancreas, liver injuries, endothelium and heart damage, i.e. dysrhythmias following reoxygenation, and blood pressure, along with effect on experimental acute/chronic inflammation, wound and fracture (pseudoarthrosis) healing are described.
It appears that these beneficial effects all together provide a particular network reflecting activity of a special peptidergic defence system. In support of this concept, it appears that there are interactions of this pentadecapeptide with many important systems (namely, dopamine-, NO-, prostaglandin-, somatosensory neurone-systems), that could provide a basis for the observed protective effects. Moreover, since disturbance of these systems’ functions (i.e. dopamine-, NO-, somatosensory neuronal-system) which manifest either over-activity or as inhibition, may contribute to the multiple lesions in different organs.
The reported evidence that this pentadecapeptide is able to counteract both their over-action, and their inhibition, may suggest this pentadecapeptide as a new, but most probably essential physiological defence system and that should be further investigated.
BPC 157 (PL-10) gastrointestinal lesions acute pancreatitis liver lesions inflammation and pain heart blood pressure behaviour physiological defence system
Useful Cited References:
- 2. Sikiric, P., Petek, M., Rucman, R., etal. (1993). A new gastric juice peptide BPC — an overview of stomach/stress/organoprotection hypothesis and BPC beneficial effects, J. Physiol. (Paris) 87,313–327.
- 3. Sikiric, P., Gyires, K., Seiwerth, S., et al. (1993). The effect of pentadecapeptide BPC 157 on inflammatory, non-inflammatory, direct and indirect pain and capsaicin neurotoxicity, Inflammopharmacology 2, 121–127.
- 4. Sikiric, P., Banic, M., Brkic, T., et al. (1993). Effects of a novel pentadecapeptide BPC 157 and methylprednisolone in a murine model of inflammatory bowel disease, Gastroenterology 104, 782.
- 5. Sikiric, P., Seiwerth, S., Grabarevic, Z., et al. (1993). Hepatoprotective effect of BPC 157, a 15-aminoacid peptide, on liver lesions induced by either restraint stress or bile duct and hepatic artery ligation or CCI4 application. A comparative study with dopamine agonists and somatostatin, Life Sci. 53, PL291-PL296.
- 6. Sikiric, P., Seiwerth, S., Grabarevic, Z., et al. (1994). The beneficial effect of BPC 157, a 15 aminoacid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. A comparative study with H2 receptor antagonists, dopamine promotors and gut peptides, Life Sci. 54, PL63-PL68.
- 7. Sikiric, P., Rotkvic, I., Mise, S. et al. (1995). Dopamine agents efficacy in peptic ulcer healing and relapse prevention — a further indication for importance of stomach dopamine in the stress organoprotection concept, in: Neuroendocrinology of Gastrointestinal Ulceration: Hans Selye Symposia on Neuroendocrinology and Stress, Szabo, S., Taché, Y. and Glavin, G. (Eds), Vol. 2, pp. 221–230. Plenum, New York.
- 8. Sikiric, P., Seiwerth, S., Grabarevic, Z., et al. (1996). Salutary and prophylactic effect of pentadecapeptide BPC 157 on acute pancreatitis and concomitant gastroduodenal lesions in rats, Digestive Disease Sci. 41, 1518–1526.
- 9. Sikiric, P., Seiwerth, S., Grabarevic, Z., et al. (1996). The beneficial effect of a novel pentadecapeptide BPC 157 on gastric lesions induced by restraint stress, ethanol, indomethacin and capsaicin neurotoxicity, Digestive Disease Sci. 41, 1604–1614.
- 10. Sikiric, P., Mazul, B., Seiwerth, S., et al. (1997). Pentadecapeptide BPC 157 interactions with adrenergic and dopaminergic systems in mucosal protection in stress, Digestive Disease Sci. 42, 661–671.
- 11. Sikiric, P., Mikus, D., Seiwerth, S., et al. (1997). Pentadecapeptide BPC 157, cimetidine, ranitidine, bromocriptine and atropine effect in cysteamine lesions in totally gastrectomized rats. A model study for cytoprotective studies, Digestive Disease Sci. 42, 1029–1037.
- 12. Sikiric, P., Seiwerth, S., Grabarevic, Z., et al. (1997). The influence of a novel pentadecapeptide BPC 157 on NG-nitro-L~arginine methylester and L-arginine effect on stomach mucosal integrity and blood pressure, European J. Pharmacol. 332, 23–33.
- 13. Grabarevic, Z., Tisljar, M., Artukovic, B., et al. (1997). The influence of BPC 157 on nitric oxide agonists and antagonist induced lesions in broiler chicks, J. Physiol. (Paris) 91, 139–150.
- 15. Jelovac, N., Sikiric, P., Rucman, R., et al. (1998). A novel pentadecapeptide BPC 157 blocks the stereotypy produced acutely by amphetamine and the developement of haloperidol-induced supersensitivity to amphetamine, Biol. Psych. 43, 511–519.CrossRef
- 16. Konjevoda, P., Nasic, M., Curkovic, T, Sikiric, P., Seiwerth, S. and Stambuk, N. (1998). Effects of BPC 157 on the healing of corneal lesions, in: Uveitis Today, Ohno, S., Aoki, K., Usui, M. and Uchio, E. (Eds), pp. 311–314. Elsevier, Amsterdam.
- 17. Kalogjera, L., Ries, N., Baudoin, T., Ferencic, Z., Protic, R. and Pegan, B. (1997). Dose dependent protective effect of BPC 157 in capasaicin induced rhinitis in rats, European Arch. Otorhinolaryngol. 254, S9-S11.
- 18. Sikiric, P., Seiwerth, S., Grabarevic, Z., et al. (1997). Pentadecapeptide BPC 157 positively affects both non-steroidal anti-inflammatory agents-induced gastrointestinal lesions and adjuvant arthritis in rats, J. Physiol. (Paris) 91, 113–122.
- 20. Sebecic, B., Nikolic, V., Sikiric, P. et al. (1999). Osteogenic effect of a gastric pentadecapeptide BPC 157, on the healing of segmental bone defect in rabbits. A comparison with bone marrow and autologous cortical bone implantation, Bone 24, 195–202.
- 21. Zoricic, I., Sikiric, P., Seiwerth, S., et al. (1997). Pentadecapeptide BPC 157 beneficially influences the healing of colon-colon anastomoses in rats, in: Cell Injury and Protection in the Gastrointestinal Tract. From basic sciences to clinical perspectives 1996, Mozsik, Gy., Nagy, L., Par, A. and Rainsford, K. D. (Eds), pp. 249–258. Kluwer Academic Publishers, Dordrecht.
- 22. Sikiric, P., Seiwerth, S., Grabarevic, Z., et al. (1997). The effect of pentadecapeptide BPC 157, H2 blockers and sucralfate on new vessels and new granulation tissue formation, Gastroenterology 112,291.
- 23. Sikiric, P., Jadrijevic, S., Seiwerth, S., et al. (1997). Pentadecapeptide BPC 157 reduces esophagojejunal anastomosis-esophageal ulceration in rats, Gastroenterology 112, 219.
- 25. Bodis, B., Karadi, O., Nagy, L., et al. (1997). Evidence for direct cellular protective effect of PL-10 substances (synthesized parts of body protection compound BPC) and their specificity to gastric mucosal cells, Life Sci. 61, PL 243-PL 248.
- 26. Veljaca, M., Pllana, R., Lesch, C. A., Sanchez, B., Chan, K. and Guglietta, A. (1994). Protective effect of BPC 157 on a rat model of colitis, Gastroenterology 106, 789.
- 27. Veljaca, M., Lech, C. A., Pllana, R., Sanchez, B., Chan, K. and Guglietta, A. (1994). BPC-15 reduces trinitrobenzene sulfonic acid-induced colonic damage in rats, J. Pharmacol. Exp. Ther. 272,417–422.
- 28. Veljaca, M, Chan, K. and Guglietta, A. (1995). Digestion of h-EGF, h-TGF α, and BPC 15 in human gastric juice, Gastroenterology 108, 761.
- 29. Veljaca, M., Lesch, C. A., Sanchez, B., Low, J. and Guglietta, A. (1995). Protection of BPC-15 on TNBS-induced colitis in rats: possible mechanisms of action, Gastroenterology 108, 936.
- 30. Bosnjak, Z. J., Graf, B. M. and Sikiric, P. (1994). Protective effects of newly isolated gastric peptide following hypoxic and reoxygenation injury in the isolated guinea pig heart, FASEB J. 8, A 129.
- 31. Sandor, Z., Vincze, A. and Szabo, S. (1996). The protective effect of a recently isolated gastric peptide in acute and chronic gastroduodenal injury, FASEB J. 10, 171.
- 32. Sandor, Z., Vincze, A., Jadus, M. R., et al. (1997). The protective effect of newly isolated peptide PL-10 in the iodoacetamide colitis model in rats, Gastroenterology 112, 400.
- 33. Paré, W. and Kluczynski, J. M. (1994). The effect of new gastric juice peptide BPC on classic stress triad in stress procedure, Exp. Clin. Gastroenterol. 2, 234–236.
- 34. Erceg, D., Simicevic, V. N., Kolega, M. and Dohoczky, C. (1997). Some aspects of PL-10.1.AK- 15 on the gastrointestinal tract, J. Physiol. (Paris) 91, 179–181.