Archive for Pain

Testimonies BPC 157 from Biotrends clients

Pro-Healer-biotrends-bpc157-101I personally would say that a key note to taking the BPC is about its anti-inflammatory capabilities through out the body.

Yes, it lets the body heal fast, it takes care of IBS’s

(Irritable Bowel Syndrome)

and more, but, concerning specifically anti-ageing, it’s its ability to reduce, even eliminate, swelling through out the body.

You and I both know, from our research, that swelling is a major cause of ageing.

This product is also included in their anti-ageing flagship “Rejuvenate Super Set” available here, on which you can get -10% by subscribing at the convenient monthly autoship here.

Here are a few testimonies I received from people using the PRO-HEALER BPC157 manufactured by Biotrends HK. I usual I removed the family names:

1.    Jack T.:  73 years old, Tulsa Oklahoma
I have been suffering from sore joints, tendons and slow to healing for many years now.  A friend of mine recommended I try Pro-Healer BPC-157 and I just felt I needed to write to you and let you know how much I appreciate this product.

The swelling and pain in my joints and the soreness of my tendons has diminished to the point that I often forget I had the problem.  As an added, unexpected, benefit, my stomach no longer hurts in the morning. Maybe I had an ulcer I was not aware of?  I did read that it helps, even can cure ulcers in a few days.  Thank you again.


2.   Roberta B.:  48,  Alberta Canada

This Pro-Healer has been a life saver for me.  I have been diagnosed with Crohn’s Disease for many years now.  Quite often the pain is unbelievable.  I have had to have 3 resections of my intestines so far and I was truly afraid of my future.

Now with the Pro-Healer, I never have pain, all the bloating and swelling is gone.  My doctor is amazed at the change I have had.

The only time I have had a problem since was when I stopped taking it last summer while I was travelling but I started again when I returned home and all is fine again.  I wish you could do an auto-ship for me.


3.        Stephan C.:  52,  Belgium

I am a diabetic and suffer from ulcers on my feet.  I have already lost 1 toe due to this problem.

I am very happy with the Pro-Healer as it has healed my skin ulcers in a very short amount of time.

I mixed it up, just as it shows on the box, and I apply it to all my wounds daily.  At first I thought it would not work, I suppose my expectations were very high and I was wanting instant results.

After a couple of days, however, it was very clear that they were healing and healing quickly.

I have tried so many different things but have never had these kind of results.  I believe that because of Pro-Healer I can manage to keep from loosing any more toes.  I am very happy, thank you so much.


➡ You can see this product here

➡ And register at Biotrends, it’s free here

Pharmacological properties of peptide BPC 157

This trial demonstrates the multi-capabilities of BPC157 to repair and protect numerous organs in our body.

 

Inflammopharmacology-Journal

Inflammo Pharmacology Journal
March 1999, Volume 7, Issue 1, pp 1-14

Abstract

The reported beneficial effects of the gastric mucosal derived pentadecapeptide BPC 157 (Gly Glu Pro Pro Pro Gly Lys Pro Ala Asp Asp Ala Gly Leu Val, M.W. 1419) on different organ lesions are reviewed.

Apart from the effects on various gastrointestinal lesions, the potentially beneficial effect on pancreas, liver injuries, endothelium and heart damage, i.e. dysrhythmias following reoxygenation, and blood pressure, along with effect on experimental acute/chronic inflammation, wound and fracture (pseudoarthrosis) healing are described.

It appears that these beneficial effects all together provide a particular network reflecting activity of a special peptidergic defence system. In support of this concept, it appears that there are interactions of this pentadecapeptide with many important systems (namely, dopamine-, NO-, prostaglandin-, somatosensory neurone-systems), that could provide a basis for the observed protective effects. Moreover, since disturbance of these systems’ functions (i.e. dopamine-, NO-, somatosensory neuronal-system) which manifest either over-activity or as inhibition, may contribute to the multiple lesions in different organs.

The reported evidence that this pentadecapeptide is able to counteract both their over-action, and their inhibition, may suggest this pentadecapeptide as a new, but most probably essential physiological defence system and that should be further investigated.

 

Key words:
BPC 157 (PL-10) gastrointestinal lesions acute pancreatitis liver lesions inflammation and pain heart blood pressure behaviour physiological defence system

Source for this article: http://link.springer.com/article/10.1007%2Fs10787-999-0022-z

 

Useful Cited References:

  • 2. Sikiric, P., Petek, M., Rucman, R., etal. (1993). A new gastric juice peptide BPC — an overview of stomach/stress/organoprotection hypothesis and BPC beneficial effects, J. Physiol. (Paris) 87,313–327.
  • 3. Sikiric, P., Gyires, K., Seiwerth, S., et al. (1993). The effect of pentadecapeptide BPC 157 on inflammatory, non-inflammatory, direct and indirect pain and capsaicin neurotoxicity, Inflammopharmacology 2, 121–127.
  • 4. Sikiric, P., Banic, M., Brkic, T., et al. (1993). Effects of a novel pentadecapeptide BPC 157 and methylprednisolone in a murine model of inflammatory bowel disease, Gastroenterology 104, 782.
  • 5. Sikiric, P., Seiwerth, S., Grabarevic, Z., et al. (1993). Hepatoprotective effect of BPC 157, a 15-aminoacid peptide, on liver lesions induced by either restraint stress or bile duct and hepatic artery ligation or CCI4 application. A comparative study with dopamine agonists and somatostatin, Life Sci. 53, PL291-PL296.
  • 6. Sikiric, P., Seiwerth, S., Grabarevic, Z., et al. (1994). The beneficial effect of BPC 157, a 15 aminoacid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. A comparative study with H2 receptor antagonists, dopamine promotors and gut peptides, Life Sci. 54, PL63-PL68.
  • 7. Sikiric, P., Rotkvic, I., Mise, S. et al. (1995). Dopamine agents efficacy in peptic ulcer healing and relapse prevention — a further indication for importance of stomach dopamine in the stress organoprotection concept, in: Neuroendocrinology of Gastrointestinal Ulceration: Hans Selye Symposia on Neuroendocrinology and Stress, Szabo, S., Taché, Y. and Glavin, G. (Eds), Vol. 2, pp. 221–230. Plenum, New York.
  • 8. Sikiric, P., Seiwerth, S., Grabarevic, Z., et al. (1996). Salutary and prophylactic effect of pentadecapeptide BPC 157 on acute pancreatitis and concomitant gastroduodenal lesions in rats, Digestive Disease Sci. 41, 1518–1526.
  • 9. Sikiric, P., Seiwerth, S., Grabarevic, Z., et al. (1996). The beneficial effect of a novel pentadecapeptide BPC 157 on gastric lesions induced by restraint stress, ethanol, indomethacin and capsaicin neurotoxicity, Digestive Disease Sci. 41, 1604–1614.
  • 10. Sikiric, P., Mazul, B., Seiwerth, S., et al. (1997). Pentadecapeptide BPC 157 interactions with adrenergic and dopaminergic systems in mucosal protection in stress, Digestive Disease Sci. 42, 661–671.
  • 11. Sikiric, P., Mikus, D., Seiwerth, S., et al. (1997). Pentadecapeptide BPC 157, cimetidine, ranitidine, bromocriptine and atropine effect in cysteamine lesions in totally gastrectomized rats. A model study for cytoprotective studies, Digestive Disease Sci. 42, 1029–1037.
  • 12. Sikiric, P., Seiwerth, S., Grabarevic, Z., et al. (1997). The influence of a novel pentadecapeptide BPC 157 on NG-nitro-L~arginine methylester and L-arginine effect on stomach mucosal integrity and blood pressure, European J. Pharmacol. 332, 23–33.
  • 13. Grabarevic, Z., Tisljar, M., Artukovic, B., et al. (1997). The influence of BPC 157 on nitric oxide agonists and antagonist induced lesions in broiler chicks, J. Physiol. (Paris) 91, 139–150.
  • 15. Jelovac, N., Sikiric, P., Rucman, R., et al. (1998). A novel pentadecapeptide BPC 157 blocks the stereotypy produced acutely by amphetamine and the developement of haloperidol-induced supersensitivity to amphetamine, Biol. Psych. 43, 511–519.CrossRef
  • 16. Konjevoda, P., Nasic, M., Curkovic, T, Sikiric, P., Seiwerth, S. and Stambuk, N. (1998). Effects of BPC 157 on the healing of corneal lesions, in: Uveitis Today, Ohno, S., Aoki, K., Usui, M. and Uchio, E. (Eds), pp. 311–314. Elsevier, Amsterdam.
  • 17. Kalogjera, L., Ries, N., Baudoin, T., Ferencic, Z., Protic, R. and Pegan, B. (1997). Dose dependent protective effect of BPC 157 in capasaicin induced rhinitis in rats, European Arch. Otorhinolaryngol. 254, S9-S11.
  • 18. Sikiric, P., Seiwerth, S., Grabarevic, Z., et al. (1997). Pentadecapeptide BPC 157 positively affects both non-steroidal anti-inflammatory agents-induced gastrointestinal lesions and adjuvant arthritis in rats, J. Physiol. (Paris) 91, 113–122.
  • 20. Sebecic, B., Nikolic, V., Sikiric, P. et al. (1999). Osteogenic effect of a gastric pentadecapeptide BPC 157, on the healing of segmental bone defect in rabbits. A comparison with bone marrow and autologous cortical bone implantation, Bone 24, 195–202.
  • 21. Zoricic, I., Sikiric, P., Seiwerth, S., et al. (1997). Pentadecapeptide BPC 157 beneficially influences the healing of colon-colon anastomoses in rats, in: Cell Injury and Protection in the Gastrointestinal Tract. From basic sciences to clinical perspectives 1996, Mozsik, Gy., Nagy, L., Par, A. and Rainsford, K. D. (Eds), pp. 249–258. Kluwer Academic Publishers, Dordrecht.
  • 22. Sikiric, P., Seiwerth, S., Grabarevic, Z., et al. (1997). The effect of pentadecapeptide BPC 157, H2 blockers and sucralfate on new vessels and new granulation tissue formation, Gastroenterology 112,291.
  • 23. Sikiric, P., Jadrijevic, S., Seiwerth, S., et al. (1997). Pentadecapeptide BPC 157 reduces esophagojejunal anastomosis-esophageal ulceration in rats, Gastroenterology 112, 219.
  • 25. Bodis, B., Karadi, O., Nagy, L., et al. (1997). Evidence for direct cellular protective effect of PL-10 substances (synthesized parts of body protection compound BPC) and their specificity to gastric mucosal cells, Life Sci. 61, PL 243-PL 248.
  • 26. Veljaca, M., Pllana, R., Lesch, C. A., Sanchez, B., Chan, K. and Guglietta, A. (1994). Protective effect of BPC 157 on a rat model of colitis, Gastroenterology 106, 789.
  • 27. Veljaca, M., Lech, C. A., Pllana, R., Sanchez, B., Chan, K. and Guglietta, A. (1994). BPC-15 reduces trinitrobenzene sulfonic acid-induced colonic damage in rats, J. Pharmacol. Exp. Ther. 272,417–422.
  • 28. Veljaca, M, Chan, K. and Guglietta, A. (1995). Digestion of h-EGF, h-TGF α, and BPC 15 in human gastric juice, Gastroenterology 108, 761.
  • 29. Veljaca, M., Lesch, C. A., Sanchez, B., Low, J. and Guglietta, A. (1995). Protection of BPC-15 on TNBS-induced colitis in rats: possible mechanisms of action, Gastroenterology 108, 936.
  • 30. Bosnjak, Z. J., Graf, B. M. and Sikiric, P. (1994). Protective effects of newly isolated gastric peptide following hypoxic and reoxygenation injury in the isolated guinea pig heart, FASEB J. 8, A 129.
  • 31. Sandor, Z., Vincze, A. and Szabo, S. (1996). The protective effect of a recently isolated gastric peptide in acute and chronic gastroduodenal injury, FASEB J. 10, 171.
  • 32. Sandor, Z., Vincze, A., Jadus, M. R., et al. (1997). The protective effect of newly isolated peptide PL-10 in the iodoacetamide colitis model in rats, Gastroenterology 112, 400.
  • 33. Paré, W. and Kluczynski, J. M. (1994). The effect of new gastric juice peptide BPC on classic stress triad in stress procedure, Exp. Clin. Gastroenterol. 2, 234–236.
  • 34. Erceg, D., Simicevic, V. N., Kolega, M. and Dohoczky, C. (1997). Some aspects of PL-10.1.AK- 15 on the gastrointestinal tract, J. Physiol. (Paris) 91, 179–181.

Salutary effect of BPC 157 on pancreatitis and gastroduodenal lesions

This trial demonstrates pancreas and gastric protection capabilities of BPC 157.

 

Digestive-Diseases-and-Sciences-JournalPancreatic And Biliary Disorders
Digestive Diseases and Sciences Journal
July 1996, Volume 41, Issue 7, pp 1518-1526

Salutary and prophylactic effect of pentadecapeptide BPC 157 on acute pancreatitis and concomitant gastroduodenal lesions in rats

 

Abstract
The superior effectiveness of a new pentadecapeptide, BPC 157, on gastrointestinal and liver lesions, in conjunction with an anti inflammatory and analgetic activity was recently noted.

In the present study, BPC 157 was tested as either a protective or healing agent in bile duct ligation-induced acute pancreatitis in rats.

In addition, the positive influence of BPC 157 on concomitantly developed gastric and duodenal lesions was simultaneously investigated.

BPC 157 (10 µg, 10 ng/kg body wt, intraperitoneally or intragastrically) was given prophylactically 1 hr before ligation, whereas the therapy was given once daily beginning with the 24 hr following ligation (last application 24 hr before killing). The effect was investigated at daily intervals until the end of the fifth day after ligation.

In the pretreatment regimen, a strong pancreas protection was obtained. When applied in the condition of already established severe acute pancreatitis, an obvious salutary effect was consistently noted. Assessing the appearance of the necrosis, edema, neutrophils, and mononuclears, consistently less necrosis, edema, and neutrophils, but more mononuclears, were found in BPC-treated rats. Likewise, in studies of the serum amylase values, relative to control data, a markedly lower rise (BPC pretreatment regimen) as well as a worsening of the already raised values (BPC therapy regimen) was noted.

Along with its beneficial effect on pancreatitis, a positive influence of BPC 157 on the gastric and duodenal lesion course in bile duct-ligated rats was noted in both the pre- and posttreatment regimen.

Taken together, in further studies of acute pancreatitis therapy, BPC could be an interesting and useful agent with an additional positive impact on concomitant gastroduodenal pathology.

 

Key words
pentadecapeptide BPC 157 acute pancreatitis gastroduodenal lesions

 

Source for this article: http://link.springer.com/article/10.1007%2FBF02088582

 

Useful Cited References:

  • 22.
    Sikiric P, Petek M, Rucman R, Grabarevic Z, Seiwerth S, Rotkvic I, Jagic V, Danilovic Z, Dodig M, Duvnjak M, Artukovic B, Dzaja P, Senecic I, Suchanek E, Giljanovic S, Mise S, Djarmanovic Z: Beneficial effect of a new gastric juice peptide, body protection compound, in acute pancreatitis models. Exp Clin Gastroenterol 1:24–25, 1991
  • 23. Sikiric P, Petek M, Rucman R, Rotkvic I, Seiwerth S, Grabarevic Z, Jagic V, Turkovic B, Mildner B, Duvnjak M, Cviko A, Kolega M, Dodig M, Sallmani A, Djacic S, Lucinger D, Erceg D: The significance of the gastroprotective effect of body protection compound (BPC): Modulation by different procedures.In Cell Injury and Protection in the Gastrointestinal Tract: From Basic Sciences to Clinical Perspectives. Gy Mózsik, A Pár, G Csomós, M Kitajima, M Kondo, CJ Pfeiffer, KD Rainsford, P Sikiric, S Szabo (eds). Budapest, Akedémiai Kiadó, 1992, pp 89–98
  • 24. Sikiric P, Petek M, Rucman R, Seiwerth S, Grabarevic Z, Rotkvic I, Jagic V, Mildner B, Duvnjak M, Lang N: A new gastric juice peptide, BPC—an overview of stomach/stress organoprotection hypothesis and BPC beneficial effects. J Physiol (Paris) 87:313–327, 1993
  • 25. Sikiric P, Seiwerth S, Grabarevic Z, Rucman R, Petek M, Rotkvic I, Turkovic B, Jagic V, Mildner B, Duvnjak M, Danilovic Z: Hepatoprotective effect of BPC 157, a 15-amino acid peptide, on liver lesions induced by either restraint stress or bile duct and hepatic artery ligation or CCl4 administration. A comparative study with dopamine agonists and somatostatin. Life Sci 53:PL291-PL296, 1993
  • 26. Sikiric P, Gyires K, Seiwerth S, Grabarevic Z, Rucman R, Petek M, Rotkvic I, Turkovic B, Udovicic I, Jagic V, Mildner B, Duvnjak M, Danilovic Z: The effect of pentadecapeptide BPC 157 on inflammatory, non-inflammatory, direct and indirect pain and capsaicin neurotoxicity. Inflammopharmacology 2:121–127, 1993
  • 27. Sikiric P, Seiwerth S, Grabarevic Z, Petek M, Rucman R, Turkovic B, Rotkvic I, Jagic V, Duvnjak M, Mise S, Djacic S, Separovic J, Veljaca M, Sallmani A, Banic M, Brkic T: The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. A comparative study with H2 receptor antagonists, dopamine promoters and gut peptides. Life Sci 54:PL63-PL68, 1994
  • 28. Seiwerth S, Grabarevic Z, Danilovic Z, Djacic S, Sikiric P, Cviko A, Kolega M: The influence of BPC 157 on incisional wound healing. Pathol Res Pract 189:809–810, 1993
  • 29. Mózsik Gy, Sikiric P, Petek M: Gastric mucosal preventing body protective compound (BPC) effect on the development of ethanol and HCl-induced gastric mucosal injury. Exp Clin Gastroenterol 1:87–90, 1991
  • 30. Paré W, Klucyznski JM: The effect of new gastric juice peptide BPC on classic stress triad in stress procedure. Exp Clin Gastroenterol 2:234–236, 1992
  • 31. Veljaca M, Pllana R, Lesch CA, Sanchez B, Chan K, Guglietta A: Protective effect of BPC 157 on a rat model of colitis. Gastroenterology 106:789, 1994
  • 32. Veljaca M, Lech CA, Pllana R, Sanchez B, Chan K, Guglietta A: BPC-15 reduces trinitrobenzene sulfonic acid-induced colonic damage in rats. J Pharmacol Exp Ther 272:417–422, 1994
  • 33. Veljaca M, Lesch CA, Sanchez B, Low J, Guglietta A: Protection of BPC-15 on TNBS-induced colitis in rats: Possible mechanisms of action. Gastroenterology 108:936, 1995
  • 34. Bosnjak ZJ, Graf BM, Sikiric P, Stowe DF: Protective effects of newly isolated gastric peptide following hypoxic and reoxygenation injury in the isolated guinea pig heart. FASEB J 8:A129, 1994
  • 35. Veljaca M, Chan K, Guglietta A: Digestion of h-EGF, h-TGF alpha, and BPC-15 in human gastric juice. Gastroenterology 108:761, 1995
  • 45. Sikiric P, Rotkvic I, Mise S, Seiwerth S, Grabarevic Z, Petek M, Rucman R, Zjacic-Rotkvic V, Duvnjak M, Jagic V, Suchanek E, Marovic A, Banic M, Brkic T, Hanzevacki M, Separovic J, Djacic S, Simicevic V: Dopamine agents efficacy in peptide ulcer healing and relapse prevention—a further indication for importance of stomach dopamine in the stress organoprotection concept.In Neuroendocrinology of Gastrointestinal Ulceration: Hans Selye Symposia on Neuroendocrinology and Stress, Vol 2., S Szabo, Y Taché, G Glavin (eds). New York, Plenum Press, 1995, pp 221–230

Effect of BPC 157 on direct and indirect pain and capsaicin neurotoxicity

This trial indicates the strong potential of BPC157 against abdominal pain.

 

Inflammopharmacology-JournalInflammo Pharmacology Journal
June 1993, Volume 2, Issue 2, pp 121-127

The effect of pentadecapeptide BPC 157 on inflammatory, non-inflammatory, direct and indirect pain and capsaicin neurotoxicity

 

Abstract
The anti-nociceptive effects of a newly synthesized pentadecapeptide coded BPC 157 (an essential fragment of new organoprotective gastric juice peptide BPC) was evaluated in comparison with aspirin and morphine reference standards, in various experimental models of indirect/direct nociception and neurotoxicity: writhing (acetic acid/magnesium sulphate), tail pinching, hot-plate, and capsaicin application.

BPC 157 administered either in the ng or μg per kg range, intraperitoneally, significantly reduced the reactions in the writhing (inflammatory and non-inflammatory, prostaglandin-dependent and independent) and tail pinching tests.

In the hot-plate test, unlike morphine, BPC 157 had no effect on normal animals. However, when given to capsaicin treated rats, BPC 157 strongly reduced capsaicin-allodynia, either given as pretreatment or once daily for 14 days after the capsaicin injection.

This reduction in capsaicin’s effect could not be obtained when BPC 157 was applied in the presence of established capsaicin-somatosensory neuron degeneration (application only on the 14th day after capsaicin), so it is possible that the effects of BPC 157 could be related specifically to the integrity of capsaicin-sensitive somatosensory neurons and their protection (e.g. primary afferent neurons having small-diameter somata and unmyelinated (C-) or thinly myelinated (A6-) fibres).

 

Keywords
pentadecapeptide BPC 157 essential fragment of organoprotective gastric juice peptide BPC writhing (acetic acid/magnesium sulphate) tail pinching test hot-plate test inflammatory/non-inflammatory, indirect/direct nociception capsaicin allodynia capsaicin-sensitive somatosensory neurons integrity/protection

Source for this article: http://link.springer.com/article/10.1007%2FBF02659088

 

Useful Cited References:

  • 2. Sikirić P, Petek M, Rotkvic I et al. Antiulcerogenic and antiinflammatory effect of a new gastric juice peptide – body protection compound. Exp Clin Gastroenterol. 1991;l:17–20.
  • 3. Sikirif P, Sciwerth S, Grabarevif Z et al. The significance of the gastroprotective effect of body protection compound (BPC): modulation by different procedures. Acta Physiol Hung. 1992;80:89–98.
  • 4. Sikirif P, Petek M, Rucman R et al. A new gastric juice peptide, BPC – an overview of stomach/stress/organoprotection hypothesis and BPC beneficial effects. J Physiol (Paris). 1993;87 [in press].
  • 5. Mppozsik G, Sikirif P, Petek M. Gastric mucosal preventing body protective compound (BPC) on the development of ethanol and HCl-induced gastric mucosal injury. Exp Clin Gastroenterol. 1991;l:87–90.