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"The most active body healing peptide available!"

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Pro-Healer or BPC 157 is an external and internal healing protein, oral and topical, applied to external sores, cuts and abrasions, will increase healing time dramatically.
Studies have shown that BPC157, taken orally, 1mg daily, can help to reverse ulcer damage, reduce inflammation through out the digestive tract and heal liver from alcohol and other damage among other things.
The trials and potential uses for this protein are endless and continuing!

Salutary effect of BPC 157 on pancreatitis and gastroduodenal lesions

This trial demonstrates pancreas and gastric protection capabilities of BPC 157.

 

Digestive-Diseases-and-Sciences-JournalPancreatic And Biliary Disorders
Digestive Diseases and Sciences Journal
July 1996, Volume 41, Issue 7, pp 1518-1526

Salutary and prophylactic effect of pentadecapeptide BPC 157 on acute pancreatitis and concomitant gastroduodenal lesions in rats

 

Abstract
The superior effectiveness of a new pentadecapeptide, BPC 157, on gastrointestinal and liver lesions, in conjunction with an anti inflammatory and analgetic activity was recently noted.

In the present study, BPC 157 was tested as either a protective or healing agent in bile duct ligation-induced acute pancreatitis in rats.

In addition, the positive influence of BPC 157 on concomitantly developed gastric and duodenal lesions was simultaneously investigated.

BPC 157 (10 µg, 10 ng/kg body wt, intraperitoneally or intragastrically) was given prophylactically 1 hr before ligation, whereas the therapy was given once daily beginning with the 24 hr following ligation (last application 24 hr before killing). The effect was investigated at daily intervals until the end of the fifth day after ligation.

In the pretreatment regimen, a strong pancreas protection was obtained. When applied in the condition of already established severe acute pancreatitis, an obvious salutary effect was consistently noted. Assessing the appearance of the necrosis, edema, neutrophils, and mononuclears, consistently less necrosis, edema, and neutrophils, but more mononuclears, were found in BPC-treated rats. Likewise, in studies of the serum amylase values, relative to control data, a markedly lower rise (BPC pretreatment regimen) as well as a worsening of the already raised values (BPC therapy regimen) was noted.

Along with its beneficial effect on pancreatitis, a positive influence of BPC 157 on the gastric and duodenal lesion course in bile duct-ligated rats was noted in both the pre- and posttreatment regimen.

Taken together, in further studies of acute pancreatitis therapy, BPC could be an interesting and useful agent with an additional positive impact on concomitant gastroduodenal pathology.

 

Key words
pentadecapeptide BPC 157 acute pancreatitis gastroduodenal lesions

 

Source for this article: http://link.springer.com/article/10.1007%2FBF02088582

 

Useful Cited References:

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    Sikiric P, Petek M, Rucman R, Grabarevic Z, Seiwerth S, Rotkvic I, Jagic V, Danilovic Z, Dodig M, Duvnjak M, Artukovic B, Dzaja P, Senecic I, Suchanek E, Giljanovic S, Mise S, Djarmanovic Z: Beneficial effect of a new gastric juice peptide, body protection compound, in acute pancreatitis models. Exp Clin Gastroenterol 1:24–25, 1991
  • 23. Sikiric P, Petek M, Rucman R, Rotkvic I, Seiwerth S, Grabarevic Z, Jagic V, Turkovic B, Mildner B, Duvnjak M, Cviko A, Kolega M, Dodig M, Sallmani A, Djacic S, Lucinger D, Erceg D: The significance of the gastroprotective effect of body protection compound (BPC): Modulation by different procedures.In Cell Injury and Protection in the Gastrointestinal Tract: From Basic Sciences to Clinical Perspectives. Gy Mózsik, A Pár, G Csomós, M Kitajima, M Kondo, CJ Pfeiffer, KD Rainsford, P Sikiric, S Szabo (eds). Budapest, Akedémiai Kiadó, 1992, pp 89–98
  • 24. Sikiric P, Petek M, Rucman R, Seiwerth S, Grabarevic Z, Rotkvic I, Jagic V, Mildner B, Duvnjak M, Lang N: A new gastric juice peptide, BPC—an overview of stomach/stress organoprotection hypothesis and BPC beneficial effects. J Physiol (Paris) 87:313–327, 1993
  • 25. Sikiric P, Seiwerth S, Grabarevic Z, Rucman R, Petek M, Rotkvic I, Turkovic B, Jagic V, Mildner B, Duvnjak M, Danilovic Z: Hepatoprotective effect of BPC 157, a 15-amino acid peptide, on liver lesions induced by either restraint stress or bile duct and hepatic artery ligation or CCl4 administration. A comparative study with dopamine agonists and somatostatin. Life Sci 53:PL291-PL296, 1993
  • 26. Sikiric P, Gyires K, Seiwerth S, Grabarevic Z, Rucman R, Petek M, Rotkvic I, Turkovic B, Udovicic I, Jagic V, Mildner B, Duvnjak M, Danilovic Z: The effect of pentadecapeptide BPC 157 on inflammatory, non-inflammatory, direct and indirect pain and capsaicin neurotoxicity. Inflammopharmacology 2:121–127, 1993
  • 27. Sikiric P, Seiwerth S, Grabarevic Z, Petek M, Rucman R, Turkovic B, Rotkvic I, Jagic V, Duvnjak M, Mise S, Djacic S, Separovic J, Veljaca M, Sallmani A, Banic M, Brkic T: The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. A comparative study with H2 receptor antagonists, dopamine promoters and gut peptides. Life Sci 54:PL63-PL68, 1994
  • 28. Seiwerth S, Grabarevic Z, Danilovic Z, Djacic S, Sikiric P, Cviko A, Kolega M: The influence of BPC 157 on incisional wound healing. Pathol Res Pract 189:809–810, 1993
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  • 32. Veljaca M, Lech CA, Pllana R, Sanchez B, Chan K, Guglietta A: BPC-15 reduces trinitrobenzene sulfonic acid-induced colonic damage in rats. J Pharmacol Exp Ther 272:417–422, 1994
  • 33. Veljaca M, Lesch CA, Sanchez B, Low J, Guglietta A: Protection of BPC-15 on TNBS-induced colitis in rats: Possible mechanisms of action. Gastroenterology 108:936, 1995
  • 34. Bosnjak ZJ, Graf BM, Sikiric P, Stowe DF: Protective effects of newly isolated gastric peptide following hypoxic and reoxygenation injury in the isolated guinea pig heart. FASEB J 8:A129, 1994
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  • 45. Sikiric P, Rotkvic I, Mise S, Seiwerth S, Grabarevic Z, Petek M, Rucman R, Zjacic-Rotkvic V, Duvnjak M, Jagic V, Suchanek E, Marovic A, Banic M, Brkic T, Hanzevacki M, Separovic J, Djacic S, Simicevic V: Dopamine agents efficacy in peptide ulcer healing and relapse prevention—a further indication for importance of stomach dopamine in the stress organoprotection concept.In Neuroendocrinology of Gastrointestinal Ulceration: Hans Selye Symposia on Neuroendocrinology and Stress, Vol 2., S Szabo, Y Taché, G Glavin (eds). New York, Plenum Press, 1995, pp 221–230

Effect of BPC 157 on direct and indirect pain and capsaicin neurotoxicity

This trial indicates the strong potential of BPC157 against abdominal pain.

 

Inflammopharmacology-JournalInflammo Pharmacology Journal
June 1993, Volume 2, Issue 2, pp 121-127

The effect of pentadecapeptide BPC 157 on inflammatory, non-inflammatory, direct and indirect pain and capsaicin neurotoxicity

 

Abstract
The anti-nociceptive effects of a newly synthesized pentadecapeptide coded BPC 157 (an essential fragment of new organoprotective gastric juice peptide BPC) was evaluated in comparison with aspirin and morphine reference standards, in various experimental models of indirect/direct nociception and neurotoxicity: writhing (acetic acid/magnesium sulphate), tail pinching, hot-plate, and capsaicin application.

BPC 157 administered either in the ng or μg per kg range, intraperitoneally, significantly reduced the reactions in the writhing (inflammatory and non-inflammatory, prostaglandin-dependent and independent) and tail pinching tests.

In the hot-plate test, unlike morphine, BPC 157 had no effect on normal animals. However, when given to capsaicin treated rats, BPC 157 strongly reduced capsaicin-allodynia, either given as pretreatment or once daily for 14 days after the capsaicin injection.

This reduction in capsaicin’s effect could not be obtained when BPC 157 was applied in the presence of established capsaicin-somatosensory neuron degeneration (application only on the 14th day after capsaicin), so it is possible that the effects of BPC 157 could be related specifically to the integrity of capsaicin-sensitive somatosensory neurons and their protection (e.g. primary afferent neurons having small-diameter somata and unmyelinated (C-) or thinly myelinated (A6-) fibres).

 

Keywords
pentadecapeptide BPC 157 essential fragment of organoprotective gastric juice peptide BPC writhing (acetic acid/magnesium sulphate) tail pinching test hot-plate test inflammatory/non-inflammatory, indirect/direct nociception capsaicin allodynia capsaicin-sensitive somatosensory neurons integrity/protection

Source for this article: http://link.springer.com/article/10.1007%2FBF02659088

 

Useful Cited References:

  • 2. Sikirić P, Petek M, Rotkvic I et al. Antiulcerogenic and antiinflammatory effect of a new gastric juice peptide – body protection compound. Exp Clin Gastroenterol. 1991;l:17–20.
  • 3. Sikirif P, Sciwerth S, Grabarevif Z et al. The significance of the gastroprotective effect of body protection compound (BPC): modulation by different procedures. Acta Physiol Hung. 1992;80:89–98.
  • 4. Sikirif P, Petek M, Rucman R et al. A new gastric juice peptide, BPC – an overview of stomach/stress/organoprotection hypothesis and BPC beneficial effects. J Physiol (Paris). 1993;87 [in press].
  • 5. Mppozsik G, Sikirif P, Petek M. Gastric mucosal preventing body protective compound (BPC) on the development of ethanol and HCl-induced gastric mucosal injury. Exp Clin Gastroenterol. 1991;l:87–90.